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Celastrol
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3001 Celastrol
3-Hydroxy-24-nor-2-oxo-1(10),
3,5,7-friedelatetraen-29-oic acid.
Tripterin
Introduction:
Celastrol is a potent anti-inflammatory that is extracted from the root bark of the Chinese Thunder of God vine (Tripterygium wilfordii Hook) an ivy-like vine in China. Celastrol was used for years as a natural remedy for inflammatory conditions.
It exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1b and IL-1a, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-a), as well as LPS-induced NF-kB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. It has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 mM). Significantly it improves the performance in memory, learning, and psychomotor activity in rats.
It may be useful to minimize inflammation in Alzheimer's disease (AD). Celastrol is a powerful antioxidant, in an isolated rat liver assay of lipidperoxidation, celastrol had a 50% inhibitory cocentration of 7 ¦ÌM, equivalent to about 15 times the antioxidant potency of a-tocopherol.
Scientists have found it to be quite intensely immunosuppressive as well as anti-inflammatory. Celastrol inhibits macrophage activation, MHC I and II processing, TNF-alpha, IL1, IL2, and IL6, it may be developed to be a new anti rheumatoid arthritis(RA) drug.
Basic Data:
CAS Number 34157-83-0
Molecular Formula C29H38O4
Formula Weight 450.6
Purity >98%
l max 422nm
C13NMR: 120.6(C-1), 178.1(C-2), 120.8(C-3), 127.5(C-4), 147.0(C-5), 135.8(C-6), 118.3(C-7), 165.0(C-8), 39.3(C-9), 173.2(C-10), 28.7(C-11), 29.3(C-12), 39.3(C-13), 43.1(C-14), 29.4(C-15), 32.4(C-16), 45.3(C-17), 44.2(C-18), 33.8(C-19), 31.30(C-20), 34.4(C-21), 36.3(C-22), 10.5(C-23), 30.6(C-24),38.3(C-25), 21.4(C-26), 18.6(C-27), 31.4(C-28), 182.6(C-29).
Stability 2 years
Storage Room temperature
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| Company: |
PAYPAYTECH SHEZHEN.LD
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| Contact: |
Mr. YI JIANG |
| Address: |
704 Fang Da Overseas Student'S Venture Bld, Shenzhen, Guangdong, China |
| Postcode: |
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| Tel: |
86 755 25849195 |
| Fax: |
86 755 25849195 |
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