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| Product Name: |
Triptolide
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98% |
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T2001 Triptolide
Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one,
3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-
(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-
Introduction:
Triptolide, a diterpene triepoxide, is a purified compound from Tripterygium wilfordii hook F that has been identified as one of the major components responsible for the immunosuppressive and anti-inflammatory effects of this herb. It exists in the extracts of Chinese herb
Tripterygium wilfordii hook F, which have been used for more than two centuries in traditional Chinese medicine to treat a variety of autoimmune and inflammatory diseases including rheumatoid arthritis. Recent explorations of the mechanisms of action of triptolide revealed many properties relevant not only to anti-inflammatory activity but also to anticancer activity.
Antiproliferative and proapoptotic activity of triptolide has been shown with many different types of cancer cells in vitro and in vivo As an immunosuppressive agent with anti-inflammatory and anti-tumor properties, it is more effective in preventing T cell proliferation and interferon-g production than FK506. It induces apoptosis in T cells by activating DEVD cleaving ca***ses, blocks TNF-amediated induction of c-IAP1 and c-IAP2 and NF-kB activation.
Triptolide also potentiates the activities of other agents and therefore may be useful not only as a single compound but also in combination with other cytotoxic drugs for cancer treatment. Its succinate salt water-soluble that is converted to triptolide in the serum, has recently been approved for Phase I clinical trials.
Basic Data:
CAS :38748-32-2
Molecular Formula: C20H24O6
MW:360.4
Source:Isolated from Tripterygium wilfordii.
Purity:>98%.
Appearance:White solid.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20 oC.
Package and Price( USD):
10mg $ 450
50mg $ 850
100mg $ 1220
500mg $ 1750
1g $ 2500
Bulk Quantity: Inquire
Shipping: Express Cou |
| Company: |
PAYPAYTECH SHEZHEN.LD
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| Contact: |
Mr. YI JIANG |
| Address: |
704 Fang Da Overseas Student'S Venture Bld, Shenzhen, Guangdong, China |
| Postcode: |
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| Tel: |
86 755 25849195 |
| Fax: |
86 755 25849195 |
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